Butyrate is a short-chain fatty acid that is a potent detoxifier of ammonia and neurotoxins. Butyrate also encourages the formation of friendly bacteria in the gut.
What exactly is Butyrate?
Butyrate is a short-chain fatty acid (SCFA) that has been combined with calcium & magnesium. It is made in the lower colon by bacteria and taken up by the colonocytes, the cells that line the colon. It then becomes an important food for those cells. Lacking good bacteria in our colon, such as when we take antibiotics, can lead to an insufficient supply of butyrate.
What is Butyrate used for?
Butyrate scrubs & cleans the liver, the gall bladder and the biliary tree. It also cleans the bowel, controls ammonia, removes ‘renegade’ fats (the very long ones that accumulate with age) and lowers the expression of inflammatory immune markers called cytokines.
What is the recommended dosage of Butyrate?
Approximately 1-2 caps with each meal, unless otherwise suggested by a Healthcare Practitioner.
How long will 1 bottle of Butyrate last?
It depends on how many you take daily - they are sold in 100 count bottles.
Can Sodium Butyrate be taken on an empty stomach?
We have never heard of any problems taking Butyrate on an empty stomach.
Are there any side effects from taking Butyrate?
None to our knowledge.
How would a person know if they should take Butyrate?
Butyrate is used in a wide array of neurological disorders. The research reports its ability to elevate cellular enzymes such as alkaline phosphatase and insufficient sodium and chloride levels. However, these are analyses (cellular enzymes or electrolytes) from a blood test which many individuals have done yearly. It’s difficult to pinpoint when you may need Butyrate, however, your health care practitioner (HCP) should be able to assist you.
The capsules of butyrate are vegetarian, made from plant cellulose. The butyrate powder within is enterically coated. Because butyrate has systemic benefits, some must then be absorbed in the upper GI tract. What people look for is to get butyrate to the colon. Here, an approach has been devised to tackle the challenge of butyrate delivery—coating with a vegetable fat, commonly cited as a medium-chain triglyceride. The rationale behind this is that a significant part of the butyrate will be released only when lipase is secreted in the duodenum.
BodyBio’s butyrates are simply butyrate, a thirteen-atom complex joined to an alkali. Butyric acid, butyrate and tributyrin are ingredients you may see in this category of supplements- same purpose, different characteristics. We use butyric acid aka butanoic acid, a short chain fatty acid with four carbon atoms at its heart (found in butter, hence its name). As an acid, it has a low pH so we compound it with an alkali, a combination that forms a salt + water. At this stage, we no longer have butyric acid, but butyrate, a buffered form of butyric acid.
These diets can be deficient in fiber & resistant starch and therefore, low in butyrate if proper dietary guidelines are not followed. When a paleo diet is properly followed, an individual should be consuming between 9-12 cups of phytonutrient and fiber rich plant foods including, green plantains, green bananas, sunchokes, artichokes, cooked and cooled potatoes, etc. in order to produce ample levels of butyrate. The problems arise when individuals focus on animal protein and fat while neglecting these plant foods/fibers.
9 cups of vegetables contain roughly 72 grams of fiber. Remember, we must also consider the health of the individual's microbiome. This factor will also influence butyrate production.
The ability for your body to synthesize butyrate depends on several factors. Dietary fiber and resistant starch intake are critical, but we also need a plethora of commensal bacteria to ferment the fiber that we eat and synthesize it into butyrate, acetate, and propionate. The state of the microbiome, the impact of drugs, alcohol, etc. factors into each individual's ability to produce short chain fatty acids like butyrate.
Chronic over nutrition via processed, nutrient void foods high in energy, fat and sugar is the norm amongst the majority of North Americans. This dietary regimen creates a situation where gut health is greatly compromised and therefore, butyrate production is greatly impaired. One cannot go wrong eating a nutrient dense diet filled with high quality animal protein and colorful, fiber rich foods.
It is important to note that most studies on butyrate are done via butyrate supplementation. Regardless of whether you are making adequate butyrate in the gut, we don't think you can go wrong by supporting your body with a top up of butyrate through supplementation. Butyrate supplementation has been showing to support a healthy gut inflammation response, improve gut integrity, inhibit histone deacetylase, blunt NF-Kappa B down, regulate activated microglia cells, and improve the gut/brain axis.